October 26, 2014 09:38 UTC

Science in the News

Autoimmune Diseases: When the Body Starts Attacking Itself

Click Arrow to Hear This Program:

Play Audio File

Or download MP3 (Right-click or option-click and save link)

BOB DOUGHTY:

This is SCIENCE IN THE NEWS, in VOA Special English. I’m Bob Doughty.

BARBARA KLEIN: And I’m Barbara Klein. This week, we talk about a sickness called lupus and other autoimmune diseases. Autoimmune diseases affect the immune system, the body’s natural defenses for fighting disease.

(MUSIC)

BOB DOUGHTY: The immune system normally protects the body against foreign materials, such as viruses and bacteria. Autoimmune diseases result from a failure of the body’s own defenses against disease. The immune system loses its ability to tell the difference between foreign materials and its own cells. So the body starts attacking its own organs and tissues.

BARBARA KLEIN: There are three kinds of lupus. Discoid lupus affects only the skin and can be identified by red marks on the face or neck. These marks on the skin can also be a sign of another form of lupus called systemic lupus. Systemic lupus can affect almost any organ or organ system in the body. When people talk about lupus, they usually mean the systemic form of the disease.

Melody Nolan, who suffers from systemic lupus, prepares her daily medications at her home in Sacramento, California
Melody Nolan, who suffers from systemic lupus, prepares her daily medications at her home in Sacramento, California

Some medicines can cause what is called drug-induced lupus. This form of lupus usually goes away when the patient stops using the medicines.

BOB DOUGHTY: High body temperature and pain in the elbows or knees are often signs of lupus. Other signs are red marks on the skin and lack of iron in the body. The person may also feel extremely tired.

At different times, the effects of lupus can be either mild or serious. The signs of the disease can come and go. This makes identifying the disease difficult. There is no single test to tell if someone has lupus. Many people with lupus also suffer from depression.

Lupus can lead to other health problems. Women with lupus are at greater risk of developing heart disease. And, between thirty and fifty percent of lupus patients will develop lupus-related kidney disease.

(MUSIC)

BARBARA KLEIN: Lupus affects an estimated one million five hundred thousand people in the United States. Experts are not sure what causes lupus. But the disease has been known to attack members of the same family.

The singer Lady Gaga announced earlier this month that she was tested for lupus. She told CNN television that the disease is genetic, and has affected members of her family. One of them is thought to have died from lupus. The singer said the testing shows that she is, in her words, borderline positive for the disease.

BOB DOUGHTY: Scientists have identified genes they believe are linked to lupus. They hope studying these genes more closely could help in development of new treatments for the disease, and possibly a cure. Recent studies also support a theory that a combination of genes is linked to the development of lupus.

Other suspected causes include antibiotic drugs, mental or physical tension, infections and hormones. In fact, hormones might explain why lupus affects women more often than men. The Lupus Foundation of America says more than ninety percent of the people with lupus are women. Scientists do not know why women are more at risk. They think it might involve female hormones, like estrogen. Another idea is that it could involve the foreign cells left in a woman’s body after a pregnancy.

BARBARA KLEIN: There is currently no cure for lupus. Yet doctors have developed ways of treating the disease. Treatments are based on the condition and needs of each patient. No two individuals have the exact same problems. A treatment could include a combination of stress-reduction methods and drugs like painkillers and steroids. Anti-malaria drugs have been effective. Research has also suggested that supervised exercise training can improve the quality of life for lupus patients.

It has been about forty years since the United States Food and Drug Administration approved a drug especially for treating lupus. Several companies are working to make drugs that can help lupus patients. Groups like the Lupus Foundation of America are working to increase public understanding of the disease.

Lupus can be life-threatening if left untreated. Yet, many patients can lead a normal and healthy life if they follow their doctor’s advice. Patients must take their medicines and keep looking for side effects or new signs of the disease.

(MUSIC)

BOB DOUGHTY: Lupus is not the only autoimmune disease. Doctors and scientists have identified at least eighty other diseases in which the body attacks its own organs and cells. Some of the diseases attack just one area of the body, like the skin, eyes or muscles. Others affect an organ system or even the whole body.

Some of the diseases are well known, such as rheumatoid arthritis, multiple sclerosis and type-one diabetes. Others are not as well known.

BARBARA KLEIN: For example, celiac disease is difficult to identify because the signs of the disease are so common. Patients may have low iron levels and experience stomach pain. The uncontrolled release of bodily wastes is also a problem.

Doctors might treat those problems and not know they are caused by celiac disease. Some people develop celiac disease after eating gluten, a protein found in wheat products. It is not always clear that eating something as harmless as wheat can be bad for a person’s health. For some patients, it can be years before the problem is correctly identified.

BOB DOUGHTY: The United States National Institutes of Health says autoimmune diseases affect an estimated five to eight percent of the country’s population. Other groups disagree. For example, the American Autoimmune Related Disease Association says autoimmune diseases affect about fifty million Americans. That represents about one-sixth of the population.

The physical, emotional and financial cost of autoimmune diseases is huge. Most of those affected are women. While people of all ages are affected, women who are old enough to have children are especially at risk.

Some autoimmune diseases like lupus and scleroderma are more common among African-Americans. Diseases like multiple sclerosis and type one diabetes are more common among whites. Doctors do not yet know why this is true.

(MUSIC)

BARBARA KLEIN: New drugs are being tested to help treat autoimmune diseases. Some drugs can be a problem because they suppress the immune system. This means the body is less able to defend itself against infections.

Newer drugs attempt to suppress only one small part of the immune system, not all of it. For example, drugs like Enbrel and Remicade block tumor necrosis factor. This is a protein that causes inflammation, a physical reaction to infection, injury or other causes. These drugs have been useful in treating diseases like rheumatoid arthritis, psoriasis and Crohn’s disease. However, the drugs are costly. And, some have been found to increase the risk of cancer.

BOB DOUGHTY: Scientists continue searching for other methods of treatment. For example, some scientists hope to use stem cells to replace tissues damaged by disease. Stem cells have the ability to grow other cells, such as heart, nerve or brain cells.

Medical experts also are working together to improve the way autoimmune diseases are identified and treated. Less than ten years ago, the Johns Hopkins Autoimmune Disease Research Center was established in Maryland. The center seeks to bring together experts to improve the study of autoimmune diseases.

Private groups show how important it is for scientists to share information about such diseases. Because each disease often affects different organs, many experts might be needed to treat the disorder. Experts need to know about the most recent research and technology. By sharing information about their patients, doctors also can learn from other cases.

BARBARA KLEIN: Government agencies are also working to increase knowledge about autoimmune diseases. In the United States, the National Institutes of Health created an autoimmune disease research plan in two thousand two. The plan urges agencies from different areas to work together.

Both private and government organizations are working to increase understanding of such diseases. This can help individuals better understand what to do should they develop a health problem. At the same time, researchers continue working to help patients have a better quality of life.

(MUSIC)

BOB DOUGHTY: This SCIENCE IN THE NEWS program written and produced by Brianna Blake. I’m Bob Doughty.

BARBARA KLEIN: And I’m Barbara Klein. Join us again next week for more news about science in Special English on the Voice of America.

This forum has been closed.
Comments
     
There are no comments in this forum. Be first and add one

Learn with The News

  • Anti-Occupy Central protesters (L) try to remove a barricade from pro-democracy protesters on a main street in Hong Kong's Mongkok shopping district October 4, 2014.

    Audio US Group Rejects Claims It Incited Hong Kong Protests

    Chinese media have been criticizing the National Endowment for Democracy. They accuse the US-based group of providing money to and advising the “Occupy” street protest movement. The group says it takes part in normal cooperation with civic groups in Hong Kong. But it says it has nothing to hide. More

  • A rocket carrying the SpaceX Dragon ship lifts off from launch complex 40 at the Cape Canaveral Air Force Station in Cape Canaveral, Florida, April 18, 2014.

    Audio You Don't Have to Be a Rocket Scientist to Read This

    "You do not need to be a rocket scientist." Americans hear these words often. People say them in schools, offices and factories. Broadcasters on radio and television use them. How did the expression begin? No one seems to know for sure. But you can find out by reading this Words and Their Stories. More

  • Audio Control of US Senate Depends on North Carolina

    U.S. congressional elections are less than two weeks away. A small number of races will decide if the Democratic party keeps control of the U.S. Senate or if Republicans will have a majority. One of the closest Senate races is in the state of North Carolina between Kay Hagan and Thom Tillis. More

  • Freed Vietnamese dissident Nguyen Van Hai (L) is greeted upon arrival at Los Angeles International Airport on October  21, 2014 in Los Angeles, California.  The Vietnamese blogger, also known by his pen name "Dieu Cay," was handed a 12-year prison sentenc

    Audio Legality of Vietnamese Blogger’s Release Questioned

    Nguyen Van Hai arrived in the United States on Wednesday. Hai is one of Vietnam’s best known political bloggers. He has written about government corruption and the country’s territorial dispute with China. The United States was among several foreign governments to call for his release. More

  • A miner sifts through dirt for gold flakes at the Atunso Cocoase small-scale mine, Atunsu, Ghana, Oct. 16, 2014. (Chris Stein/VOA)

    Audio Gold Mining in Ghana Can Be Dangerous

    Small mining operations are a common sight in central Ghana. Here, mine workers dig deep into the earth in search of bullion. But not everyone returns alive. Earlier this year, six miners were killed when an earthen wall collapsed in Kyekyewere, a village in the Ashanti Region. More

Featured Stories

  • Audio Oscar de la Renta Dressed First Ladies and Movie Stars

    Clothing designer Oscar de la Renta died Monday at his home in the American state of Connecticut. He was 82 years old. His wife said he died of problems related to cancer. Mr. de la Renta dressed American movie stars and first ladies such as Jacqueline Kennedy, Nancy Reagan and Hillary Clinton. More

  • Audio Iron Ships Clash at Sea

    The American Civil War was fought not only on land, but at sea. In 1862, Confederate and Union forces fought a new kind of navy battle in waters off Hampton Roads, Virginia. It was the first battle between iron ships. On the Confederate side was a ship called the Virginia. | The Making of a Nation More

  • Audio San Francisco Radio Stations Ban Lorde's 'Royals'

    The California baseball team, San Francisco Giants, is playing the Kansas City Royals for the 2014 Major League Baseball championship, the World Series. Two radio stations in San Francisco banned the hit song "Royals." In return, another station in Kansas City chose to play the song once every hour. More

  • A neurovascular unit on a chip being developed by Vanderbilt University researchers. (Vanderbilt University Photo/John Wikswo)

    Video Scientists Design Chips to Act Like Human Organs

    Testing new drugs for safety and effectiveness is a costly process in the United States. It also can take a lot of time. Some scientists are now designing silicon computer chips that act like human organs. The scientists think they have found a way to make the process faster and more economical. More

  • Brain Resource Infographic

    Audio Dealing with Distractions and Overreactions

    Five million American children and teenagers have Attention Deficit / Hyperactivity Disorder, commonly known as ADHD. ADHD makes it difficult - if not impossible - to stay with a duty until it is complete. Katherine Ellison knows the problem well. | Health Report More

Practice Your Writing

Confessions of an English Learner BlogConfessions of an English Learner Blog

Tell us About Our Programs