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Designing an Alternative to Antibiotics

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Researchers say anti-bacterial protein, PlyC could be effective antibiotic alternativeResearchers say anti-bacterial protein, PlyC could be effective antibiotic alternative
Researchers say anti-bacterial protein, PlyC could be effective antibiotic alternative
Researchers say anti-bacterial protein, PlyC could be effective antibiotic alternative


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This is the VOA Special English Health Report.
In nineteen twenty-eight a British scientist made a "chance observation." He noticed that some mold had grown in bacteria in a culture plate in his laboratory. Molds can do that. But this mold that had somehow gotten into the plate had the ability to kill the bacteria around it.
The scientist, Alexander Fleming, found that the mold was a member of a common group known as Penicillium. Fleming and two other scientists -- Ernst Boris Chain and Howard Walter Florey -- went on to win the Nobel Prize in nineteen forty-five. They were honored "for the discovery of penicillin and its curative effect in various infectious diseases."
Other powerful antibiotics have been discovered since penicillin. But many antibiotics have become less and less effective as the germs they are designed to kill develop resistance.
So scientists are searching for new ways to treat infections. Now, researchers in Australia say they have made a important discovery. Scientists at Monash University in Melbourne believe an antibacterial viral protein called PlyC could be used as an alternative to antibiotics.
This protein was first identified as a possible treatment for infections in nineteen twenty-five. But the research ended following the discovery of antibiotics.
Now, scientists have spent six years studying the structure of the protein. They have found how it kills the bacteria that cause sore throats, pneumonia and streptococcal toxic shock syndrome.
Australian researchers worked with scientists at the Rockefeller University in New York and the University of Maryland. Their findings appear in the Proceedings of the National Academy of Sciences.
Dr. Sheena McGowan from Monash University describes the protein as a powerful bacterial killing machine. She says it looks like a flying saucer carrying a pair of warheads. It connects to the surface of the bacterium and then cuts though the outside to destroy it.
Sheena McGowan says it could be highly valuable when conditions like pneumonia do not respond to traditional treatments.
SHEENA MCGOWAN: "There's antibiotics at the moment for those particular types of diseases. We sort of see that there's a bit of resistance being built up in the bacterial community almost, and some of our antibiotics aren't quite as effective as they used to be. So this kind of ground route, basic research needs to be done quite early so that we have some time to develop them as safe human therapeutic over the timeframe when the antibiotics can keep working."
 The researchers have been studying PlyC's atomic structure to try to develop a drug. They say they have had success in treating streptococcal infections in mice. But an effective human treatment in the form of a pill or nasal spray may be at least ten years away.
And that's the VOA Special English Health Report. I'm Steve Ember.
Contributing: Phil Mercer
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Comment Sorting
by: Farouk from: Baghdad-Iraq
08/19/2012 8:16 AM
God bless America for her dignity and seeking for global health.Amin...

by: Nargiz from: Azerbaijan
08/15/2012 9:13 AM
Thanks for the article

by: Takahiro from: Japan
08/10/2012 12:30 AM
Dear VOA Special English

Hello. I am Japanese student studing English. I read VOA special English every day. I really like this website!

I found a little spelling mistake in this article "Designing an Alternative to Antibiotics".

>It connects to the surface of the bacterium and then cuts
>though the outside to destroy it.

I think "though" -> "through".

sincerely yours

08/09/2012 4:11 PM
Wow! Very useful information. The discovery of antibiotics was a great milestone in the history of the medical world. Whatever side effects they may have, its immune system strengthening power is quite unquestionable. And I'm delighted to know that scientists are sweating their eye brows to replace antibiotics with plyC. It is a blessing that scientists were able to detect bacteria's drug resisting power in time. I wonder why scientists couldn't discover a solution to curb the free play of 'viruses' as well. Waiting that much is too much. Thank you VOA.

by: Yoshi from: Sapporo
08/08/2012 4:08 AM
What an innovative way to kill germs ! A hint of innovation may often be submerged in the water of history ?

by: tcc from: Taiwan
08/08/2012 1:36 AM
I think the new treatment will be great because unlike other treatment like antibiotics,this is a kind of protein.It may be more safer (I think).